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Homologous over-extension: a challenge for iterative similarity searches
We have characterized a novel type of PSI-BLAST error, homologous over-extension (HOE), using embedded PFAM domain queries on searches against a reference library containing Pfam-annotated UniProt sequences and random synthetic sequences. PSI-BLAST makes two types of errors: alignments to non-homolo...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853128/ https://ncbi.nlm.nih.gov/pubmed/20064877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1219 |
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