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MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing
Muscleblind-like 1 (MBNL1) regulates alternative splicing and is a key player in the disease mechanism of myotonic dystrophy (DM). In DM, MBNL1 becomes sequestered to expanded CUG/CCUG repeat RNAs resulting in splicing defects, which lead to disease symptoms. In order to understand MBNL1’s role in b...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853123/ https://ncbi.nlm.nih.gov/pubmed/20071745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1209 |
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