A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3′–5′ and 5′–3′ strands by rotating a single active site

Metal-dependent nucleases that generate double-strand breaks in DNA often possess two symmetrically-equivalent subunits, arranged so that the active sites from each subunit act on opposite DNA strands. Restriction endonuclease BfiI belongs to the phospholipase D (PLD) superfamily and does not requir...

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Detalles Bibliográficos
Autores principales: Sasnauskas, Giedrius, Zakrys, Linas, Zaremba, Mindaugas, Cosstick, Richard, Gaynor, James W., Halford, Stephen E., Siksnys, Virginijus
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853115/
https://ncbi.nlm.nih.gov/pubmed/20047964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1194
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