Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

BACKGROUND: Vulval intraepithelial neoplasia (VIN) is a premalignant condition, which is frequently associated with type HPV16 infection, and multifocal disease has high rates of surgical treatment failure. METHODS: We report a phase II clinical trial of the topical immunomodulator, imiquimod, for 8...

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Main Authors: Daayana, S, Elkord, E, Winters, U, Pawlita, M, Roden, R, Stern, P L, Kitchener, H C
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853099/
https://ncbi.nlm.nih.gov/pubmed/20234368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605611
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