Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

Intestinal barrier function is reduced in inflammatory bowel disease (IBD). Tumor necrosis factor (TNF) and interleukin (IL)-13, which are up-regulated in IBD, induce barrier defects that are associated with myosin light chain kinase (MLCK) activation and increased claudin-2 expression, respectively...

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Autors principals: Weber, Christopher R., Raleigh, David R., Su, Liping, Shen, Le, Sullivan, Erika A., Wang, Yingmin, Turner, Jerrold R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852941/
https://ncbi.nlm.nih.gov/pubmed/20177070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064808
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