An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium

PURPOSE: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations. Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabo...

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Main Authors: Tung, Jai-Nien, Wu, Heng-Hsiung, Chiang, Chun-Chi, Tsai, Yi-Yu, Chou, Ming-Chih, Lee, Huei, Cheng, Ya-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852619/
https://ncbi.nlm.nih.gov/pubmed/20700368
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