Interaction between Age and Obesity on Cardiomyocyte Contractile Function: Role of Leptin and Stress Signaling

OBJECTIVES: This study was designed to evaluate the interaction between aging and obesity on cardiac contractile and intracellular Ca(2+) properties. METHODS: Cardiomyocytes from young (4-mo) and aging (12- and 18-mo) male lean and the leptin deficient ob/ob obese mice were treated with leptin (0.5,...

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Detalhes bibliográficos
Main Authors: Ren, Jun, Dong, Feng, Cai, Guo-Jun, Zhao, Peng, Nunn, Jennifer M., Wold, Loren E., Pei, Jianming
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852499/
https://ncbi.nlm.nih.gov/pubmed/20396382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010085
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