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Novel Small Molecules Relieve Prothymosin α-Mediated Inhibition of Apoptosome Formation by Blocking Its Interaction with Apaf-1
Structurally diverse small molecules, including 5–(2–Benzofuryl)-4-phenyl-1,2,4-triazole-3-thiol (BETT), have been identified via high-throughput screening as activators of caspase-3 in HeLa cell extracts. However, little is known about their mechanism of action. In this study, we investigate how BE...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2852139/ https://ncbi.nlm.nih.gov/pubmed/20121050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9022329 |
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