The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation

The phosphatase and tensin homolog (PTEN) is a tumor suppressor that is inactivated in many human cancers. PTEN loss has been associated with resistance to inhibitors of the epidermal growth factor receptor (EGFR), but the molecular basis of this resistance is unclear. It is believed that unopposed...

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Bibliografiska uppgifter
Huvudupphovsmän: Vivanco, Igor, Rohle, Daniel, Versele, Matthias, Iwanami, Akio, Kuga, Daisuke, Oldrini, Barbara, Tanaka, Kazuhiro, Dang, Julie, Kubek, Sara, Palaskas, Nicolaos, Hsueh, Teli, Evans, Michael, Mulholland, David, Wolle, Daniel, Rajasekaran, Sigrid, Rajasekaran, Ayyappan, Liau, Linda M., Cloughesy, Timothy F., Dikic, Ivan, Brennan, Cameron, Wu, Hong, Mischel, Paul S., Perera, Timothy, Mellinghoff, Ingo K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851999/
https://ncbi.nlm.nih.gov/pubmed/20308550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911188107
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