Manganese Superoxide Dismutase V16A Single-Nucleotide Polymorphism in the Mitochondrial Targeting Sequence Is Associated with Reduced Enzymatic Activity in Cryopreserved Human Hepatocytes

Mitochondrial manganese superoxide dismutase (MnSOD), encoded by the SOD2 gene, represents a major cellular defense against environmental carcinogens that cause oxidative stress. Two single-nucleotide polymorphisms −9 T>C (V16A in the MnSOD mitochondrial targeting sequence) and −102 C>T (in th...

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Detaylı Bibliyografya
Asıl Yazarlar: Martin, Robert C.G., Li, Yan, Liu, Qiahong, Jensen, Neil S., Barker, David F., Doll, Mark A., Hein, David W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc. 2009
Konular:
Original Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851837/
https://ncbi.nlm.nih.gov/pubmed/18821846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2008.0788
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