Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

Aging of the hematopoietic stem cell compartment is believed to contribute to the onset of a variety of age-dependent blood cell pathophysiologies. Mechanistic drivers of hematopoietic stem cell (HSC) aging include DNA damage accumulation and induction of tumor suppressor pathways that combine to re...

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Detaylı Bibliyografya
Asıl Yazarlar: Beerman, Isabel, Bhattacharya, Deepta, Zandi, Sasan, Sigvardsson, Mikael, Weissman, Irving L., Bryder, David, Rossi, Derrick J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851806/
https://ncbi.nlm.nih.gov/pubmed/20304793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000834107
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