Antagonism of Tetherin Restriction of HIV-1 Release by Vpu Involves Binding and Sequestration of the Restriction Factor in a Perinuclear Compartment

The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface. Recent reports proposed β-TrCP-dependent proteasomal and/or endo-lysosomal degradation of Tetherin as potential mechanisms by which...

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Hauptverfasser: Dubé, Mathieu, Bhusan Roy, Bibhuti, Guiot-Guillain, Pierre, Binette, Julie, Mercier, Johanne, Chiasson, Antoine, Cohen, Éric A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851737/
https://ncbi.nlm.nih.gov/pubmed/20386718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000856
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