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A Mycobacterium tuberculosis Sigma Factor Network Responds to Cell-Envelope Damage by the Promising Anti-Mycobacterial Thioridazine

BACKGROUND: Novel therapeutics are urgently needed to control tuberculosis (TB). Thioridazine (THZ) is a candidate for the therapy of multidrug and extensively drug-resistant TB. METHODOLOGY/PRINCIPAL FINDINGS: We studied the impact of THZ on Mycobacterium tuberculosis (Mtb) by analyzing gene expres...

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Autors principals: Dutta, Noton K., Mehra, Smriti, Kaushal, Deepak
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851646/
https://ncbi.nlm.nih.gov/pubmed/20386700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010069
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