Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes

BACKGROUND: The intracellular and plasma concentrations of HIV protease inhibitors (HPIs) vary widely in vivo. It is unclear whether there is a concentration-dependent effect of HPIs such that at increasing concentration they may either block their own efflux (leading to ‘autoboosting’) or influx (l...

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Autores principales: Janneh, Omar, Bray, Patrick G., Jones, Elizabeth, Wyen, Christoph, Chiba, Peter, Back, David J., Khoo, Saye H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851493/
https://ncbi.nlm.nih.gov/pubmed/20237075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq082
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