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Hydrogen tunneling in adenosylcobalamin-dependent glutamate mutase: evidence from intrinsic kinetic isotope effects measured by intra-molecular competition

Hydrogen atom transfer reactions between substrate and coenzyme are a key mechanistic feature of all AdoCbl-dependent enzymes. For one of these enzymes, glutamate mutase, we have investigated whether hydrogen tunneling makes a significant contribution to the mechanism by examining the temperature-de...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Yoon, Miri, Song, Hangtian, Håkansson, Kristina, Marsh, E. Neil G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851448/
https://ncbi.nlm.nih.gov/pubmed/20225826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1001695
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