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New insights into the molecular mechanism of amyloid formation from cysteine scanning

Our laboratory recently reported the identification of a peptide region, QVNI, within the prion domain of the yeast protein Ure2 that may act as an initiation point for fibril formation.1 This potential amyloid-forming region, which corresponds to residues 18–21 of Ure2, was initially identified by...

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Autori principali: Fei, Li, Perrett, Sarah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850414/
https://ncbi.nlm.nih.gov/pubmed/20083897
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