The anti-protozoal drug pentamidine blocks K(IR)2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel

BACKGROUND AND PURPOSE: Pentamidine is a drug used in treatment of protozoal infections. Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias associated with QTc prolongation and U-wave alterations. This proarrhythmic effect was linked to inhibition of hERG trafficki...

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Detalhes bibliográficos
Main Authors: de Boer, TP, Nalos, L, Stary, A, Kok, B, Houtman, MJC, Antoons, G, van Veen, TAB, Beekman, JDM, de Groot, BL, Opthof, T, Rook, MB, Vos, MA, van der Heyden, MAG
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850409/
https://ncbi.nlm.nih.gov/pubmed/20180941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00658.x
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