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Reduced expression of the Ca(2+) transporter protein PMCA2 slows Ca(2+) dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination

Cerebellar Purkinje neurones (PNs) express high levels of the plasma membrane calcium ATPase, PMCA2, a transporter protein critical for the clearance of calcium from excitable cells. Genetic deletion of one PMCA2 encoding gene in heterozygous PMCA2 knock-out (PMCA2(+/−)) mice enabled us to determine...

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Autori principali: Empson, Ruth M, Turner, Paul R, Nagaraja, Raghavendra Y, Beesley, Philip W, Knöpfel, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849958/
https://ncbi.nlm.nih.gov/pubmed/20083513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.182196
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