Clumping Factor A Interaction with Complement Factor I Increases C3b Cleavage on the Bacterial Surface of Staphylococcus aureus and Decreases Complement-Mediated Phagocytosis

The human complement system is important in the immunological control of Staphylococcus aureus infection. We showed previously that S. aureus surface protein clumping factor A (ClfA), when expressed in recombinant form, bound complement control protein factor I and increased factor I cleavage of C3b...

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Главные авторы: Hair, Pamela S., Echague, Charlene G., Sholl, Amber M., Watkins, Justin A., Geoghegan, Joan A., Foster, Timothy J., Cunnion, Kenji M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2010
Предметы:
Molecular Pathogenesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849425/
https://ncbi.nlm.nih.gov/pubmed/20100856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01065-09
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