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Toll-Like Receptor 3 Agonist Protection against Experimental Francisella tularensis Respiratory Tract Infection

We investigated whether Toll-like receptor 3 (TLR3) stimulation would protect the host from inhaled Francisella tularensis. TLR3 is expressed by respiratory epithelial cells and macrophages and can be activated by a synthetic double-stranded RNA ligand called polyinosine-polycytosine [poly(I:C)]. Th...

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Detalhes bibliográficos
Main Authors: Pyles, Richard B., Jezek, G. Eric, Eaves-Pyles, Tonyia D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849393/
https://ncbi.nlm.nih.gov/pubmed/20123717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00736-09
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