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Genetic Dissection of Azole Resistance Mechanisms in Candida albicans and Their Validation in a Mouse Model of Disseminated Infection

Principal mechanisms of resistance to azole antifungals include the upregulation of multidrug transporters and the modification of the target enzyme, a cytochrome P450 (Erg11) involved in the 14α-demethylation of ergosterol. These mechanisms are often combined in azole-resistant Candida albicans iso...

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Hlavní autoři: MacCallum, Donna M., Coste, Alix, Ischer, Françoise, Jacobsen, Mette D., Odds, Frank C., Sanglard, Dominique
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849354/
https://ncbi.nlm.nih.gov/pubmed/20086148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01645-09
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