GENETIC AND ENVIRONMENTAL INFLUENCES ON THE RATIO OF 3’HYDROXYCOTININE TO COTININE IN PLASMA AND URINE

OBJECTIVES: The ratio of trans-3’hydroxycotinine/cotinine (3HC/COT) is a marker of CYP2A6 activity, an important determinant of nicotine metabolism. This analysis sought to conduct a combined genetic epidemiologic and pharmacogenetic investigation of the 3HC/COT ratio in plasma and urine. METHODS: O...

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Hlavní autoři: Swan, Gary E., Lessov-Schlaggar, Christina N., Bergen, Andrew W., He, Yungang, Tyndale, Rachel F., Benowitz, Neal L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849278/
https://ncbi.nlm.nih.gov/pubmed/19300303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32832a404f
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