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Parallel Multiplicative Target Screening Against Divergent Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential

Typically, biochemical screens that employ pure macromolecular components focus on single targets or a small number of interacting components. Researches rely on whole cell screens for more complex systems. Bacterial DNA replicases contain multiple subunits that change interactions with each stage o...

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Detalhes bibliográficos
Main Authors: Dallmann, H. Garry, Fackelmayer, Oliver J., Tomer, Guy, Chen, Joe, Wiktor-Becker, Anna, Ferrara, Tracey, Pope, Casey, Oliveira, Marcos T., Burgers, Peter M. J., Kaguni, Laurie S., McHenry, Charles S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849275/
https://ncbi.nlm.nih.gov/pubmed/20184361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9020764
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