APP Anterograde Transport Requires Rab3A GTPase Activity for Assembly of the Transport Vesicle

The amyloid precursor protein (APP) is anterogradely transported by conventional kinesin in a distinct transport vesicle, but both the biochemical composition of such a vesicle and the specific kinesin-1 motor responsible for transport are poorly defined. APP may be sequentially cleaved by β- and γ-...

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Autors principals: Szodorai, Anita, Kuan, Yung-Hui, Hunzelmann, Silke, Engel, Ulrike, Sakane, Ayuko, Sasaki, Takuya, Takai, Yoshimi, Kirsch, Joachim, Müller, Ulrike, Beyreuther, Konrad, Brady, Scott, Morfini, Gerardo, Kins, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849269/
https://ncbi.nlm.nih.gov/pubmed/19923287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1546-09.2009
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