Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

The longevity-assurance activity of the tumor suppressor p53 depends on the levels of Δ40p53 (p44), a short and naturally occurring isoform of the p53 gene. As such, increased dosage of p44 in the mouse leads to accelerated aging and short lifespan. Here we show that mice homozygous for a transgene...

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Detalhes bibliográficos
Main Authors: Pehar, Mariana, O’Riordan, Kenneth J, Burns-Cusato, Melissa, Andrzejewski, Matthew E, del Alcazar, Carlos Gil, Burger, Corinna, Scrable, Heidi, Puglielli, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848983/
https://ncbi.nlm.nih.gov/pubmed/20409077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2010.00547.x
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