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Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?

For years conventional drug design at G-protein coupled receptors (GPCRs) has mainly focused on the inhibition of a single receptor at a usually well-defined ligand-binding site. The recent discovery of more and more physiologically relevant GPCR dimers/oligomers suggests that selectively targeting...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Filizola, Marta
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2009
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848910/
https://ncbi.nlm.nih.gov/pubmed/19465029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2009.05.004
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