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Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E
It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors (gender, diet, smoking, alcohol, exercise) that,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2848859/ https://ncbi.nlm.nih.gov/pubmed/20368805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010022 |
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