Age-Dependent Signature of Metallothionein Expression in Primary CD4 T Cell Responses Is Due to Sustained Zinc Signaling

The ability to mount adaptive immune responses to vaccinations and viral infections declines with increasing age. To identify mechanisms leading to immunosenescence, primary CD4 T cell responses were examined in 60- to 75-year-old individuals lacking overt functional defects. Transcriptome analysis...

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Detalhes bibliográficos
Main Authors: Lee, Won-Woo, Cui, Dapeng, Czesnikiewicz-Guzik, Marta, Vencio, Ricardo Z.N., Shmulevich, Ilya, Aderem, Alan, Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2008
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848531/
https://ncbi.nlm.nih.gov/pubmed/19072254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/rej.2008.0747
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