LINE-1 Methylation in Plasma DNA as a Biomarker of Activity of DNA Methylation Inhibitors in Patients with Solid Tumors

Multiple clinical trials are investigating the use of the DNA methylation inhibitors azacitidine and decitabine for the treatment of solid tumors. Clinical trials in hematological malignancies have shown that optimal activity does not occur at their maximum tolerated doses but selection of an optima...

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Main Authors: Aparicio, Ana, North, Brittany, Barske, Lindsey, Wang, Xuemei, Bollati, Valentina, Weisenberger, Daniel, Yoo, Christine, Tannir, Nizar, Horne, Erin, Groshen, Susan, Jones, Peter, Yang, Allen, Issa, Jean-Pierre
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848123/
https://ncbi.nlm.nih.gov/pubmed/19421002
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