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A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death
Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2J(Bax+/−) mice exhibited complete resistance to nerve damage after 2 w...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Neurochemistry
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847828/ https://ncbi.nlm.nih.gov/pubmed/20360947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20100003 |
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