Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

Plasma FGF21 levels and hepatic FGF21 gene expression increase dramatically after birth in mice. This induction is initiated by suckling, requires lipid intake, is impaired in PPARα null neonates, and is mimicked by treatment with the PPARα activator, Wy14,643. Neonates exhibit reduced FGF21 express...

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Hauptverfasser: Hondares, Elayne, Rosell, Meritxell, Gonzalez, Frank J., Giralt, Marta, Iglesias, Roser, Villarroya, Francesc
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847690/
https://ncbi.nlm.nih.gov/pubmed/20197053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.02.001
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