Sprouty Genes Control Diastema Tooth Development via Bidirectional Antagonism of Epithelial-Mesenchymal FGF Signaling

Unlike humans, who have a continuous row of teeth, mice have only molars and incisors separated by a toothless region called a diastema. Although tooth buds form in the embryonic diastema, they regress and do not develop into teeth. Here, we identify members of the Sprouty (Spry) family, which encod...

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Main Authors: Klein, Ophir D., Minowada, George, Peterkova, Renata, Kangas, Aapo, Yu, Benjamin D., Lesot, Herve, Peterka, Miroslav, Jernvall, Jukka, Martin, Gail R.
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847684/
https://ncbi.nlm.nih.gov/pubmed/16890158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2006.05.014
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