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Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR

P58(IPK) may function as an ER molecular chaperone to maintain protein folding homeostasis during Unfolded Protein Responses (UPR). P58(IPK) contains nine TPR motifs and a C-terminal J-domain within its primary sequence. To investigate the mechanism how P58(IPK) functions to promote protein folding...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Tao, Jiahui, Petrova, Kseniya, Ron, David, Sha, Bingdong
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847029/
https://ncbi.nlm.nih.gov/pubmed/20184891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.02.028
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