Variables with time-varying effects and the Cox model: Some statistical concepts illustrated with a prognostic factor study in breast cancer

BACKGROUND: The Cox model relies on the proportional hazards (PH) assumption, implying that the factors investigated have a constant impact on the hazard - or risk - over time. We emphasize the importance of this assumption and the misleading conclusions that can be inferred if it is violated; this...

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Hauptverfasser: Bellera, Carine A, MacGrogan, Gaëtan, Debled, Marc, de Lara, Christine Tunon, Brouste, Véronique, Mathoulin-Pélissier, Simone
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846954/
https://ncbi.nlm.nih.gov/pubmed/20233435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-10-20
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