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Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications

More than one million patients will manifest colorectal cancer (CRC) this year of which, conservatively, approximately 3% (~30,700 cases) will have Lynch syndrome (LS), the most common hereditary CRC predisposing syndrome. Each case belongs to a family with clinical needs that require genetic counse...

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Detalhes bibliográficos
Main Authors: Lynch, HT, Lynch, PM, Lanspa, SJ, Snyder, CL, Lynch, JF, Boland, CR
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846640/
https://ncbi.nlm.nih.gov/pubmed/19659756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1399-0004.2009.01230.x
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