Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1

Synaptic spines are dynamic structures that regulate neuronal responsiveness and plasticity. Here we describe a role for the schizophrenia risk factor, Disrupted-in-Schizophrenia 1 (DISC1), in the maintenance of spine morphology and function. We show that DISC1 anchors Kalirin-7 (Kal-7) thereby regu...

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Detalhes bibliográficos
Main Authors: Hayashi-Takagi, Akiko, Takaki, Manabu, Graziane, Nick, Seshadri, Saurav, Murdoch, Hannah, Dunlop, Allan J, Makino, Yuichi, Seshadri, Anupamaa J, Ishizuka, Koko, Srivastava, Deepak P., Xie, Zhong, Baraban, Jay M., Houslay, Miles D., Tomoda, Toshifumi, Brandon, Nicholas J., Kamiya, Atsushi, Yan, Zhen, Penzes, Peter, Sawa, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846623/
https://ncbi.nlm.nih.gov/pubmed/20139976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2487
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