Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1

Synaptic spines are dynamic structures that regulate neuronal responsiveness and plasticity. Here we describe a role for the schizophrenia risk factor, Disrupted-in-Schizophrenia 1 (DISC1), in the maintenance of spine morphology and function. We show that DISC1 anchors Kalirin-7 (Kal-7) thereby regu...

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Autori principali: Hayashi-Takagi, Akiko, Takaki, Manabu, Graziane, Nick, Seshadri, Saurav, Murdoch, Hannah, Dunlop, Allan J, Makino, Yuichi, Seshadri, Anupamaa J, Ishizuka, Koko, Srivastava, Deepak P., Xie, Zhong, Baraban, Jay M., Houslay, Miles D., Tomoda, Toshifumi, Brandon, Nicholas J., Kamiya, Atsushi, Yan, Zhen, Penzes, Peter, Sawa, Akira
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846623/
https://ncbi.nlm.nih.gov/pubmed/20139976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2487
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