Activities of the benzoxazinorifamycin KRM 1648 and ethambutol against Mycobacterium avium complex in vitro and in macrophages.

KRM 1648 is a 4-aminobenzoxazine derivative of rifamycin S with potent in vitro activity against the Mycobacterium avium complex (MAC); the MIC for 90% of 24 MAC isolates from AIDS patients was 0.25 microgram/ml as determined by a radiometric broth macrodilution assay. KRM 1648 was bactericidal for...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Inderlied, C B, Barbara-Burnham, L, Wu, M, Young, L S, Bermudez, L E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284646/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7986017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.8.1838
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