Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation

PURPOSE: Ionizing radiation, an important component of glioma therapy, is critically dependent on tumor oxygenation. However, gliomas are notable for areas of necrosis and hypoxia, which foster radioresistance. We hypothesized that pharmacologic manipulation of the typically dysfunctional tumor vasc...

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Detalhes bibliográficos
Main Authors: McGee, Mackenzie C., Hamner, J. Blair, Williams, Regan F., Rosati, Shannon F., Sims, Thomas L., Ng, Catherine Y., Gaber, M. Waleed, Calabrese, Christopher, Wu, Jianrong, Nathwani, Amit C., Duntsch, Christopher, Merchant, Thomas E., Davidoff, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846307/
https://ncbi.nlm.nih.gov/pubmed/20338480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2009.12.010
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