Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation

PURPOSE: Ionizing radiation, an important component of glioma therapy, is critically dependent on tumor oxygenation. However, gliomas are notable for areas of necrosis and hypoxia, which foster radioresistance. We hypothesized that pharmacologic manipulation of the typically dysfunctional tumor vasc...

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Main Authors: McGee, Mackenzie C., Hamner, J. Blair, Williams, Regan F., Rosati, Shannon F., Sims, Thomas L., Ng, Catherine Y., Gaber, M. Waleed, Calabrese, Christopher, Wu, Jianrong, Nathwani, Amit C., Duntsch, Christopher, Merchant, Thomas E., Davidoff, Andrew M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846307/
https://ncbi.nlm.nih.gov/pubmed/20338480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2009.12.010
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