A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity

The prevalence of asthma continues to increase in westernized countries, and optimal treatment remains a significant therapeutic challenge. Recently, CD1d-restricted invariant NKT (iNKT) cells were found to play a critical role in the induction of airway hyperreactivity (AHR) in animal models and ar...

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Main Authors: Lombardi, Vincent, Stock, Philippe, Singh, Abinav K., Kerzerho, Jerome, Yang, Wen, Sullivan, Barbara A., Li, Xiangming, Shiratsuchi, Takayuki, Hnatiuk, Nathan E., Howell, Amy R., Yu, Karl O. A., Porcelli, Steven A., Tsuji, Moriya, Kronenberg, Mitchell, Wilson, S. Brian, Akbari, Omid
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845715/
https://ncbi.nlm.nih.gov/pubmed/20083656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901208
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