Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides.

beta-L-2',3'-Dideoxycytidine (beta-L-ddC) and beta-L-5-fluoro-2',3'-dideoxycytidine (5-F-beta-L-ddC) were prepared and shown to have potent activity against human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV). These compounds were compared with beta-D-2',...

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Autors principals: Van Draanen, N A, Tisdale, M, Parry, N R, Jansen, R, Dornsife, R E, Tuttle, J V, Averett, D R, Koszalka, G W
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC284558/
https://ncbi.nlm.nih.gov/pubmed/7518218
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