Regulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir.

Alpha interferon (IFN-alpha) and acyclovir (ACV) are synergistic in their anti-herpes simplex virus activities. IFN-alpha treatment reduced the herpes simplex virus thymidine kinase (TK) activity present in cells 6 h postinfection, while steady-state levels of TK mRNA remained at or above the amount...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Taylor, J L, Tom, P, Guy, J, Selvarajan, R M, O'Brien, W J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8031058/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.4.853
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