γH2A binds Brc1 to maintain genome integrity during S-phase

ATM(Tel1) and ATR(Rad3) checkpoint kinases phosphorylate the C-terminus of histone H2AX (H2A in yeasts) in chromatin flanking DNA damage, establishing a recruitment platform for checkpoint and repair proteins. Phospho-H2A/X (γH2A/X)-binding proteins at double-strand breaks (DSBs) have been character...

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Autors principals: Williams, Jessica S, Williams, R Scott, Dovey, Claire L, Guenther, Grant, Tainer, John A, Russell, Paul
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845269/
https://ncbi.nlm.nih.gov/pubmed/20094029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.413
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