Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro.

MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil or I-EBU) has recently been identified as a highly potent and specific inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Since the compound has favorable pharmacokinetic and toxicity profiles in vivo, we have evaluated...

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Detalhes bibliográficos
Main Authors: Baba, M, Shigeta, S, Yuasa, S, Takashima, H, Sekiya, K, Ubasawa, M, Tanaka, H, Miyasaka, T, Walker, R T, De Clercq, E
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC284526/
https://ncbi.nlm.nih.gov/pubmed/7518216
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