A double point mutation in PCL-γ1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation

Growth factor stimulation induces Y783 phosphorylation of phosphoinositide-specific PLC-γ1, and the subsequent activation of this enzyme in a cellular signaling cascade. Previously, we showed that a double point mutation, Y509A/F510A, of PLC-γ1, abolished interactions with translational elongation f...

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Autors principals: Chung, Sang-Hee, Kim, Sung-Kuk, Kim, Jung Kuk, Yang, Yong-Ryoul, Suh, Pann-Ghill, Chang, Jong-Soo
Format: Artigo
Idioma:Inglês
Publicat: Korean Society for Biochemistry and Molecular Biology 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845006/
https://ncbi.nlm.nih.gov/pubmed/20164676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2010.42.3.023
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