Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

OBJECTIVE: Sirtuins (SIRTs) are NAD(+)-dependent deacetylases that regulate metabolism and life span. We used peripheral blood mononuclear cells (PBMCs) to determine ex vivo whether insulin resistance/metabolic syndrome influences SIRTs. We also assessed the potential mechanisms linking metabolic al...

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Detalhes bibliográficos
Main Authors: de Kreutzenberg, Saula Vigili, Ceolotto, Giulio, Papparella, Italia, Bortoluzzi, Alessia, Semplicini, Andrea, Man, Chiara Dalla, Cobelli, Claudio, Fadini, Gian Paolo, Avogaro, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844808/
https://ncbi.nlm.nih.gov/pubmed/20068143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1187
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