Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice.

Polymyxin B nonapeptide, derived by cleavage of the fatty acyl diaminobutyric acid from polymyxin B, is considerably less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes. The pepti...

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Bibliografiske detaljer
Main Authors: Ofek, I, Cohen, S, Rahmani, R, Kabha, K, Tamarkin, D, Herzig, Y, Rubinstein, E
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC284461/
https://ncbi.nlm.nih.gov/pubmed/8192470
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