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MMP-2 Induced Vein Relaxation via Inhibition of [Ca(2+)](e)-Dependent Mechanisms of Venous Smooth Muscle Contraction. Role of RGD Peptides

BACKGROUND: Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of varicose veins. We have shown that MMP-2 causes relaxation of venous segments and suggested a role of venous smooth muscle (VSM) hyperpolarization; however, the downstream mechanisms are unclear. We tested whether MMP...

詳細記述

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書誌詳細
主要な著者: Raffetto, Joseph D., Barros, Yaskara V. R., Wells, Amanda K., Khalil, Raouf A.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844458/
https://ncbi.nlm.nih.gov/pubmed/19482300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2008.09.022
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