Resistance to 2',3'-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase.

A human immunodeficiency virus type 1 variant resistant to zalcitabine (2',3'-dideoxycytidine [ddC]) was selected by sequential passage in the presence of increasing concentrations of ddC in peripheral blood mononuclear cell cultures. A mutation causing a lysine-to-arginine substitution was noted in...

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Publicado en:	Antimicrob Agents Chemother
Principais autores:	Zhang, D, Caliendo, A M, Eron, J J, DeVore, K M, Kaplan, J C, Hirsch, M S, D'Aquila, R T
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7514856/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.2.282
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