In-vivo transfection of pcDNA3.1-IGFBP7 inhibits melanoma growth in mice through apoptosis induction and VEGF downexpression

BACKGROUND: Genome-wide RNA interference screening study revealed that loss of expression of insulin-like growth factor binding protein 7 (IGFBP7) is a critical step in development of a malignant melanoma (MM), and this secreted protein plays a central role in apoptosis of MM. In this study we const...

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Bibliografske podrobnosti
Main Authors: Chen, Rong-Yi, Chen, Hong-Xiang, Lin, Jia-Xi, She, Wei-Bing, Jiang, Ping, Xu, Li, Tu, Ya-Ting
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844372/
https://ncbi.nlm.nih.gov/pubmed/20158915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-29-13
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