Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys

Human parainfluenza viruses (HPIVs) are common causes of severe pediatric respiratory viral disease. We characterized wild-type HPIV2 infection in an in vitro model of human airway epithelium (HAE) and found that the virus replicates to high titer, sheds apically, targets ciliated cells, and induces...

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Main Authors: Schaap-Nutt, Anne, Scull, Margaret A., Schmidt, Alexander C., Murphy, Brian R., Pickles, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. Published by Elsevier Ltd. 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844349/
https://ncbi.nlm.nih.gov/pubmed/20139039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.01.050
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