Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys

Human parainfluenza viruses (HPIVs) are common causes of severe pediatric respiratory viral disease. We characterized wild-type HPIV2 infection in an in vitro model of human airway epithelium (HAE) and found that the virus replicates to high titer, sheds apically, targets ciliated cells, and induces...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Schaap-Nutt, Anne, Scull, Margaret A., Schmidt, Alexander C., Murphy, Brian R., Pickles, Raymond J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier Ltd. Published by Elsevier Ltd. 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844349/
https://ncbi.nlm.nih.gov/pubmed/20139039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.01.050
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